JOB SUMMARY
We are seeking a Machine Learning Scientist to join the Enchant team at Iambic Therapeutics. Our mission is to deliver better medicines through innovation in AI-based discovery technologies. In this role, you will research and develop post-training methods for Enchant - our multimodal transformer model trained on a wide variety of biomedical data - pushing the boundaries of what large-scale foundation models can achieve in drug discovery.
The role centers on designing and evaluating post-training approaches for large multimodal language models including supervised fine-tuning, parameter-efficient fine-tuning, reinforcement learning, preference or reward-based optimization, and other emerging post-training methods. You will develop rigorous evaluations and training infrastructure that make it possible to rapidly iterate on these approaches at scale and work closely with colleagues across machine learning, software engineering, and drug discovery to put powerful foundation models into the hands of scientists making real therapeutic decisions.
We are hiring across multiple levels and welcome candidates ranging from recent PhD graduates to experienced researchers with a strong publication or deployment record. This is a remote position, with the option to be on-site in our Bristol office.
KEY RESPONSIBILITIES
Research and develop post-training strategies for large-scale multimodal foundation models
Design reward functions, training objectives, data-generation strategies, and evaluation protocols for reinforcement learning and other post-training approaches applied to multimodal LLMs
Build systematic experimentation and hyperparameter optimization workflows to efficiently explore post-training recipes, model configurations, and training strategies
Develop and apply inference optimization techniques to support deployment in both high-throughput model evaluation and interactive discovery workflows
Design and maintain rigorous benchmarking and evaluation frameworks that measure model quality across modalities, downstream tasks, and scientific use cases
Collaborate with ML and software engineering colleagues to productionize models, evaluation systems, and inference services
Partner with computational chemists, medicinal chemists, and biologists to ensure model development and post-training objectives are grounded in drug discovery needs
Communicate results to internal teams, external partners, and at conferences
Write high-quality research and engineering code: refactor, test, document, and package ML components to support team velocity
QUALIFICATIONS
PhD in machine learning, computer science, computational chemistry, physics, or a related computational STEM field, or equivalent industry experience demonstrating comparable depth
Strong Python and PyTorch skills, including implementing, training, debugging and evaluating deep learning models end-to-end
Demonstrated experience training large-scale transformer models
Demonstrated experience in one or more of the following:
Reinforcement learning approaches such as RLHF, RLAIF, PPO, GRPO, RL with verifiable rewards, or related methods (strongly preferred)
Supervised fine-tuning, full-parameter fine-tuning, parameter-efficient fine-tuning (LoRA), or related methods
Systematic hyperparameter optimization or large-scale experimentation using tools such as Optuna, Ray Tune, or similar frameworks
Strong engineering practices: reproducible experimentation, clean code, testing, and performance-aware debugging
Comfort with modern ML infrastructure (e.g., Docker, CUDA, Kubernetes, experiment tracking tools such as Weights & Biases)
PREFERRED
Experience with multimodal or multi-task model architectures
Training and inference optimization (e.g., mixed precision, kernel optimization, quantization, distributed strategies)
Familiarity with biomedical, chemical, or biological data domains
Distributed training at scale
HPC or large-scale training operations experience
ABOUT IAMBIC THERAPEUTICS
Iambic Therapeutics (Nasdaq: IAM) is a technology and clinical-stage life sciences company headquartered in San Diego. By utilizing molecular superintelligence — integrating proprietary AI with automated, scalable chemistry and biology experimentation — our platform is designed to address the totality of drug discovery and development. At Iambic, we are building an engine that is designed to power the future of medicine. Learn more at iambic.ai.
MISSION & VALUES
Our mission is to make better technology for better medicines. Three values guide how we work:
Bold. We are courageous, take thoughtful risks, and approach challenges with tenacity.
Innovative. We are creative and find new solutions that deliver impact.
Collaborative. We respect one another and partner with integrity.
We value the range of perspectives our people bring, and we work to build an environment where every team member can contribute and grow.
PAY AND BENEFITS
We offer a competitive compensation package, private medical insurance, life assurance, pension contributions, and flexible holiday allowances to our team. Our UK office provides a modern and collaborative work environment, right in the centre of Bristol.
EQUAL OPPORTUNITY
Iambic is an equal opportunity employer. We consider all qualified applicants without regard to race, color, religion, sex, sexual orientation, gender identity or expression, national origin, ancestry, age, disability, medical condition, genetic information, marital status, veteran or military status, or any other characteristic protected by law.